Lavender (Lavandula officinalis) essential oil prevents acetaminophen-induced hepatotoxicity by decreasing oxidative stress and inflammatory response

Acetaminophen (N-acetyl-p-aminophenol, APAP) is the most popular drug recommended and consumed for relieving mild moderate pain fever. Although effective in therapeutic doses, APAP overdose induces hepatotoxicity, causing acute liver failure. In this study, hepatoprotective effects underlying mechanisms of Lavandula officinalis essential oil (LEO) were investigated APAP-induced hepatotoxicity. To evaluate effect, Balb /c mice pretreated with LEO at doses 200 400 mg/kg, once daily seven days. On seventh day, treated (250 mg/kg) to induce significantly decreased serum levels alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (?-GT) compared group. Besides, a decrease myeloperoxidase (MPO) activity, nitric oxide (NO), pro-inflammatory cytokines observed samples mice. Moreover, pretreatment showed significant antioxidant activity by decreasing malondialdehyde (MDA), carbonylated proteins, reactive oxygen species (ROS), glutathione (GSH), addition increasing hepatic superoxide dismutase (SOD), catalase (CAT), oxidized (GSSG). Our results that improved functions altered inhibiting oxidative stress inflammatory induced other stress-mediated toxicities.